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Hundreds of scientists working at Laboratorycontribute research published in major research journals, in the fields of Cancer, Neuroscience, Plant Biology, Quantitative Biology, and Genomics.

Evolving sets of gene regulators explain some of our differences from other primates

1/29/2018

What makes us different from our primate relatives? Gene regulation is one important evolutionary factor Read the story »

New method to determine before surgery which prostate tumors pose a lethal threat

12/1/2017

The news about prostate cancer can be confusing. It鈥檚 the third most common cancer type among Americans. Read the story »

First cell-type census of mouse brains: surprises about structure, male-female differences

10/5/2017

A multiyear project in the Brain Initiative, qBrain is already revealing the brain as never before. Read the story »

Neuron types in the brain are defined by gene activity that shapes their communication patterns

9/21/2017

Neurons are defined by determining which cells they connect with and how they communicate across synapses Read the story »

Plant geneticists develop a new application of CRISPR to break yield barriers in crops

9/14/2017

Mutating regulatory regions varies yield traits the way a dimmer switch controls a light bulb Read the story »

Long-sought mechanism of metastasis is discovered in pancreatic cancer

7/27/2017

An epigenetic factor reprograms gene enhancers, enabling cancer cells to 鈥渞emember鈥� an earlier developmental state and causing metastasis. Read the story »

Freeze-frames of enzymes in action have implications for a new cancer treatment concept

7/3/2017

TUTase enzymes interact with let-7, a regulator of development; targeting them could help control certain cancers. Read the story »

Newly identified small RNA fragments defend the genome when it鈥檚鈥榥aked鈥�

6/29/2017

Fragments snipped from tRNAs protect embryonic stem cells while they鈥檙e being epigenetically reprogrammed. Read the story »

Detailed new 鈥榬eference鈥� genome for maize shows the plant has deep resources for continued adaptation

6/12/2017

A new, much more detailed reference genome for maize, or corn, as it is called in the U.S., provides new insight into the crop. Read the story »

Protein complex that takes first steps in human DNA replication dance is captured at high atomic resolution

3/16/2017

Human ORC complex captured in action in x-ray crystallography and cryo-EM Read the story »

Dopamine neurons factor ambiguity into predictions that enable us to 鈥渨in big and win often鈥�

3/9/2017

Researchers describe how dopamine-releasing neurons weigh the ambiguity of sensory information, indicating that neurons are highly sophisticated. Read the story »

Discovery of distinct cell subtypes around tumors helps explain why pancreatic cancer is so hard to treat

2/23/2017

Researchers finds that stroma,鈥渨ound鈥�-like tissue that surrounds the tumors, helps explain why pancreatic cancer is so resistant to treatment. Read the story »

Researchers identify “Achilles鈥� heel” of PTEN that helps drive prostate cancer progression

2/13/2017

Researchers at Laboratoryhave discovered that a protein called Importin-11 protects the anti-cancer protein PTEN from destruction by transporting it. Read the story »

Relationship between incorrect chromosome number and cancer is reassessed after surprising experiments

1/12/2017

Pre-malignant aneuploid cells grew more slowly and formed smaller tumors than comparable cells with normal chromosome number, Laboratoryresearchers found. Read the story »

Gene editing yields tomatoes that flower and ripen weeks earlier

12/5/2016

Researchers use CRISPR to expand the geographical range of important food crops. Read the story »

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