麻豆传媒社区

LaboratoryMenu
Semir Beyaz

Semir Beyaz

Assistant Professor
Cancer Center Member

Ph.D., Harvard University, 2017

beyaz@cshl.edu | 516-367-4128

Are you really what you eat? Our goal is to uncover the precise mechanisms that link nutrition to organismal health and disease states at the cellular and molecular level. A particular focus in our lab is to understand how dietary perturbations affect the immune system and contribute to the risk of diseases that are associated with immune dysfunction such as cancer.

Cells respond and adapt to the signals that they receive from their environment. Environmental factors such as nutrients affect cellular states by altering cell state-specific gene expression or metabolic programs. My research group investigates the causal cellular and molecular mechanisms that link nutrition to organismal health and disease. For example, diets that lead to obesity, such as high fat diets are significant environmental risk factors that influence cancer incidence and progression in several tissues. Although the interactions between tumor cells and the immune system play a significant role in tumorigenesis, little is known about how dietary perturbations impact immunity against cancer. Our studies interrogate the functional consequences of diets on immune recognition and response pathways that play critical role in cancer immunity. By identifying the altered gene expression and metabolic programs in the immune system in response to dietary perturbations, our goal is to uncover mechanistic links that can be therapeutically exploited for the treatment of diseases associated with immune dysfunction such as cancer.

LaboratoryFellow Semir Beyaz wins three awards
The Janeway Award, New England Immunology Conference
Trainee Award, American Association of Immunologists
Outstanding Poster Award, International Society for Stem Cell Research
Zhongmei Chen Yong Travel Award for Scientific Excellence, International Society for Stem Cell Research
Merit Award, International Society for Stem Cell Research
Thermo-Fisher Trainee Achievement Award, American Association of Immunologists



See all Beyaz news

Selected Publications

1 Apr 2021 | Cell Stem Cell | 28(4):598-599
Beyaz, Semir;  Mana, Miyeko;  Yilmaz, Ömer;  

15 Oct 2020 | Mucosal Immunology
Gaudino, S;  Beaupre, M;  Lin, X;  Joshi, P;  Rathi, S;  McLaughlin, P;  Kempen, C;  Mehta, N;  Eskiocak, O;  Yueh, B;  Blumberg, R;  van der Velden, A;  Shroyer, K;  Bialkowska, A;  Beyaz, S;  Kumar, P;  

8 Sep 2020 | bioRxiv
Beyaz, S;  Roper, J;  Bauer-Rowe, K;  Xifaras, M;  Ergin, I;  Dohnalova, L;  Biton, M;  Shekar, K;  Mou, H;  Eskiocak, O;  Ozata, D;  Papciak, K;  Chung, C;  Almeqdadi, M;  Fein, M;  Valle-Encinas, E;  Erdemir, A;  Dogum, K;  Garipcan, A;  Meyer, H;  Fox, J;  Elinav, E;  Kucukural, A;  Kumar, P;  McAleer, J;  Thaiss, C;  Regev, A;  Orkin, S;  Yilmaz, O;  

3 Feb 2020 | Nature Reviews Immunology | 20(5):308-320
Ordovas-Montanes, J;  Beyaz, S;  Rakoff-Nahoum, S;  Shalek, A;  

25 Jul 2019 | Gastroenterology | 157(5)
Luo, Y;  Yang, Y;  Liu, M;  Wang, D;  Wang, F;  Bi, Y;  Ji, J;  Li, S;  Liu, Y;  Chen, R;  Huang, H;  Wang, X;  Swidnicka-Siergiejko, A;  Janowitz, T;  Beyaz, S;  Wang, G;  Xu, S;  Bialkowska, A;  Luo, C;  Pin, C;  Liang, G;  Lu, X;  Wu, M;  Shroyer, K;  Wolff, R;  Plunkett, W;  Ji, B;  Li, Z;  Li, E;  Li, X;  Yang, V;  Logsdon, C;  Abbruzzese, J;  Lu, W;  

All Publications

20 Oct 2024 | Bio-protocol | 14(20):e5093
Barbi, Mali;  Gowthaman, Divya;  Katcher, Arielle;  Gorman, Megan;  Yueh, Brian;  Nizam, Aaron;  Chung, Charlie;  Akyildiz, Erdogan;  Frimer, Marina;  Goldberg, Gary;  Beyaz, Semir;  

7 Aug 2024 | Nature
Soula, Mariluz;  Unlu, Gokhan;  Welch, Rachel;  Chudnovskiy, Aleksey;  Uygur, Beste;  Shah, Vyom;  Alwaseem, Hanan;  Bunk, Paul;  Subramanyam, Vishvak;  Yeh, Hsi-Wen;  Khan, Artem;  Heissel, Søren;  Goodarzi, Hani;  Victora, Gabriel;  Beyaz, Semir;  Birsoy, K谋vanç;  

11 Jun 2024 | Nature Microbiology
Tierney, Braden;  Kim, JangKeun;  Overbey, Eliah;  Ryon, Krista;  Foox, Jonathan;  Sierra, Maria;  Bhattacharya, Chandrima;  Damle, Namita;  Najjar, Deena;  Park, Jiwoon;  Garcia Medina, J;  Houerbi, Nadia;  Meydan, Cem;  Wain Hirschberg, Jeremy;  Qiu, Jake;  Kleinman, Ashley;  Al-Ghalith, Gabriel;  MacKay, Matthew;  Afshin, Evan;  Dhir, Raja;  Borg, Joseph;  Gatt, Christine;  Brereton, Nicholas;  Readhead, Benjamin;  Beyaz, Semir;  Venkateswaran, Kasthuri;  Wiseman, Kelly;  Moreno, Juan;  Boddicker, Andrew;  Zhao, Junhua;  Lajoie, Bryan;  Scott, Ryan;  Altomare, Andrew;  Kruglyak, Semyon;  Levy, Shawn;  Church, George;  Mason, Christopher;  

22 Mar 2024 | bioRxiv
Eskiocak, Onur;  Chowdhury, Saria;  Shah, Vyom;  Nnuji-John, Emmanuella;  Chung, Charlie;  Boyer, Jacob;  Harris, Alexander;  Habel, Jill;  Sadelain, Michel;  Beyaz, Semir;  Amor, Corina;  

21 Feb 2024 | Nature Communications | 15(1):1597
Gaudino, Stephen;  Singh, Ankita;  Huang, Huakang;  Padiadpu, Jyothi;  Jean-Pierre, Makheni;  Kempen, Cody;  Bahadur, Tej;  Shiomitsu, Kiyoshi;  Blumberg, Richard;  Shroyer, Kenneth;  Beyaz, Semir;  Shulzhenko, Natalia;  Morgun, Andrey;  Kumar, Pawan;